Locoregional Recurrence in ER+ HER2– Breast Cancer: Clinical Reality, Therapeutic Uncertainty, and the Need for Biologic Insight - Live

March 17, 2026

Webinar Information

Webinar Description

Locoregional recurrence (LRR) in breast cancer remains a clinically significant event associated with increased risk of distant metastasis and breast cancer–specific mortality. While advances in surgery, radiation, and systemic therapy have reduced recurrence rates, management of LRR—particularly in estrogen receptor–positive (ER+), HER2-negative disease—remains highly variable and is often guided by clinical judgment rather than tumor biology. This talk will review current patterns of locoregional recurrence, associated outcomes, and contemporary treatment approaches, highlighting areas of uncertainty in systemic therapy decision-making. The session will also introduce ongoing research aimed at understanding the molecular evolution of ER+ HER2– tumors at the time of recurrence, with the goal of informing more biologically driven treatment strategies during what may represent the final potentially curative opportunity.

Learning Objectives

  • Describe clinical patterns of locoregional recurrence in ER+ HER2– breast cancer
  • Recognize gaps in biologic understanding of ER+ HER2– locoregional recurrence
  • Explain the rationale for studying tumor evolution at the time of recurrence
  • Discuss current treatment approaches following locoregional recurrence

 

Using the Learning Portal

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Webinar Registration


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Attending the Webinar

  • Attend online using the link above.
  • Attend in person at North Carolina Basnight Cancer Hospital, Sanofi Aventis Conference Room 1.

Instructions

See our instructions for more information on registering attendance and receiving credit.

Contact us with any questions at [email protected] or (919) 445–1000.

 

Course summary
Available credit: 
  • 1.00 ABIM Medical Knowledge
  • 1.00 AMA PRA Category 1 Credit™
Course opens: 
01/16/2026
Course expires: 
03/24/2026
Event starts: 
03/17/2026 - 4:00pm EDT
Event ends: 
03/17/2026 - 5:00pm EDT
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Cancer Grand Rounds Logo 

The Lineberger Cancer Center Grand Rounds are educational activities regarding cancer. We cover the most relevant oncology topics.

These webinars provide FREE continuing education credit.

UNC Lineberger Cancer Grand Rounds are presented as a hybrid event with in-person and online viewing options. 

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In-person at:
Conference Room 1 at the N.C. Basnight Cancer Hospital		 


Online via Zoom:
Link will be provided in confirmation email

 

Photo of Meghan Flanagan, MD, MPH 

Meghan Flanagan, MD, MPH

Assistant Professor
Surgery
School of Medicine
University of Washington

Disclosures

Activity Planners
This activity has been planned and implemented under the sole supervision of the Course Directors, Jared Weiss, MD; Deborah Marie Stephens, DO; and Kaitlin Morrison, PhD, of the UNC School of Medicine in association with the UNC Office of Continuing Professional Development (CPD). Dr. Weiss is a stockholder in Vesselon, Nuvalent, En Fuego Therapeutics, Vertex, Merus, Revmed; receives consulting fees from AZ, EMD Serono, Nanobiotix, PDS, Amgen, Pharmacosmos, GSK; and receives research grants from Pharmacosmos, Loxo, PDS, Genmab, Iovance, Nurix, TSCAN, Janus, BMS, Summit. These financial relationships have been mitigated. Dr. Stephens has served on advisory boards for Abbvie, AstraZeneca, BeOne, BMS, Genentech, Pfizer, Pharmacyclics, J&J. These were one time consulting efforts, but she is asked periodically to serve on additional boards. She is a consultant for Abbvie and this is an ongoing relationship. She has also received research grants research grants to Lineberger Comprehensive Cancer Center from BeOne, which are ongoing. Dr. Morrison has no relevant financial relationships with ineligible companies as defined by the ACCME. CPD staff have no relevant financial relationships with ineligible companies as defined by the ACCME. The planning committee members and their relevant financial relationships with ineligible companies as defined by the ACCME can be found at https://learn.unclcn.org/content/lineberger-cancer-center-grand-rounds-planning-committee.

Speaker
The presenter has no relevant financial relationships with ineligible companies as defined by the ACCME.

 

Accreditation Statements

1.00 ABIM MOC Part 2 Credit
CME MOC ABIM badge
Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC Part 2 credit.

1.00 AMA PRA Category 1 Credit™
The School of Medicine of The University of North Carolina at Chapel Hill designates this activity for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

The School of Medicine of the University of North Carolina at Chapel Hill designates this live internet activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

 

Notice

Attendees are required to view a minimum of 53 minutes of the live webinar video to receive CME credit.

Available Credit

  • 1.00 ABIM Medical Knowledge
  • 1.00 AMA PRA Category 1 Credit™
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