Where the Rubber Hits the Road: Genomic Biomarkers in Breast Cancer Clinical Decision-Making - ABIM MOC Part 2- Live

November 18, 2025

Webinar Information

Webinar Description

Lisa Carey, MD, FASCO, ScM, offers a clinically grounded tour of how genomic and immune biomarkers are transforming breast cancer care, from early-stage treatment decisions to metastatic disease management. Dr. Lisa Carey reviews the dramatic improvements in survival driven by targeted therapies, the biology underlying intrinsic tumor and immune subtypes, and the strengths and limitations of major biomarker assays in ER-positive, HER2-positive, and triple-negative breast cancers. Using evidence from large genomic datasets and key trials—including CALGB 40601, CALGB 40603, HER2DX development, and ongoing studies such as HARMONY—she illustrates how tumor subtype, immune activation, and molecular heterogeneity influence response to therapy, recurrence risk, and treatment tailoring. The session highlights where biomarkers work well, where they fall short, and what’s coming next, providing clinicians with a practical framework for matching the right patient to the right treatment at the right time.

Learning Objectives

  • Recognize the state of breast cancer treatment and challenges to developing biomarkers to guide therapy.
  • Identify current and emerging predictive and prognostic biomarkers in nonmetastatic breast cancer.
  • Understand the genomic differences between metastatic and nonmetastatic breast cancer and the implications for biomarkerdevelopment.

 

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Course summary
Available credit: 
  • 1.00 ABIM Medical Knowledge
  • 1.00 AMA PRA Category 1 Credit™
Course opens: 
10/13/2025
Course expires: 
11/25/2025
Event starts: 
11/18/2025 - 4:00pm EST
Event ends: 
11/18/2025 - 5:00pm EST
Part of: 
Where the Rubber Hits the Road: Genomic Biomarkers in Breast Cancer Clinical Decision-Making- Parent- Live
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Photo of Lisa Carey, MD, FASCO, ScM 

Lisa Carey, MD, FASCO, ScM

The L. Richardson and Marilyn Jacobs Preyer Distinguished Professor for Breast Cancer Research
Division of Oncology
UNC Lineberger Comprehensive Cancer Center
UNC School of Medicine
University of North Carolina at Chapel Hill

Disclosures

Activity Directors
This activity has been planned and implemented under the sole supervision of the Course Directors, Jared Weiss, MD; Deborah Marie Stephens, DO; and Kaitlin Morrison, PhD, of the UNC School of Medicine in association with the UNC Office of Continuing Professional Development (CPD). Dr. Weiss is a stockholder in Vesselon, Nuvalent, En Fuego Therapeutics, Vertex, Merus, Revmed; receives consulting fees from AZ, EMD Serono, Nanobiotix, PDS, Amgen, Pharmacosmos, GSK; and receives research grants from Pharmacosmos, Loxo, PDS, Genmab, Iovance, Nurix, TSCAN, Janus, BMS, Summit. These financial relationships have been mitigated. Dr. Stephens has served on advisory boards for Abbvie, AstraZeneca, BeOne, BMS, Genentech, Pfizer, Pharmacyclics, J&J. These were one time consulting efforts, but she is asked periodically to serve on additional boards. She is a consultant for Abbvie and this is an ongoing relationship. She has also received research grants research grants to Lineberger Comprehensive Cancer Center from BeOne, which are ongoing. Dr. Morrison has no relevant financial relationships with ineligible companies as defined by the ACCME. CPD staff have no relevant financial relationships with ineligible companies as defined by the ACCME. The planning committee members and their relevant financial relationships with ineligible companies as defined by the ACCME can be found at https://learn.unclcn.org/content/lineberger-cancer-center-grand-rounds-planning-committee.

ABIM MOC Part 2 Credit
No one with the ability to control content of this activity has a relevant financial relationship with an ineligible company. The presenter has no relevant financial relationships with ineligible companies as defined by the ACCME.

ACCME
No one with the ability to control content of this activity has a relevant financial relationship with an ineligible company. The presenter has no relevant financial relationships with ineligible companies as defined by the ACCME.

 

Accreditation Statements

1.00 ABIM MOC Part 2 Credit
CME MOC ABIM badge
Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC Part 2 credit.

1.00 AMA PRA Category 1 Credit™
The School of Medicine of The University of North Carolina at Chapel Hill designates this activity for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

The School of Medicine of the University of North Carolina at Chapel Hill designates this live internet activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

 

Notice

In most cases, regulations prohibit the repeated use of the same educational activity (Live Webinar or Self-Paced, Online Course but not both) as it relates to satisfying CE requirements to maintain licensure. Attendees are also required to view a minimum of 53 minutes of the live webinar video to receive CE credit. Please contact your individual accreditation agencies for more details.

Altering or submitting modified certificates constitutes fraud that can result in punitive action by the accrediting agency.

Available Credit

  • 1.00 ABIM Medical Knowledge
  • 1.00 AMA PRA Category 1 Credit™
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