Psycho-oncology or psychosocial oncology is a sub-specialty of oncology that addresses the psychological, behavioral, emotional, and social issues that arise for cancer patients and their families. A cancer diagnosis, the treatments that follow, and the adverse effects of cancer treatments are all very distressing for patients. Psycho-oncology includes providers from various disciplines that work together as a team to best support the complex needs people face when struggling with cancer. This lecture focuses on the psychiatric care of patients with cancer and looks at the common psychiatric syndromes seen in psycho-oncology, appropriate medications and treatment plans, and how psychiatry can best support people with cancer. Untreated or poorly managed psychiatric syndromes, such as depression and anxiety, can have a profound negative impact on decision-making, compliance, and quality of life during cancer care.